Bendamustine

Drug Profile

Bendamustine

Alternative Names: BENDA; Bendam; Bendamus; Bendamustine HCl; Bendamustine hydrochloride; Bentaman; Cytostasan; Endexin; Esevaril; Innomustine; Levact; Ribomustin; Ribomustine; Ribovact; SDX-105; SyB L-0501; Symbenda; Treakisym; Treanda

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Astellas Pharma GmbH
  • Developer Astellas Pharma GmbH; Cantonal Hospital of St Gallen; Eisai Co Ltd; Foundation GIMEMA; GlaxoSmithKline KK; INNOPHARMAX; Istituto Clinico Humanitas; Janssen-Cilag; Memorial Sloan-Kettering Cancer Center; Mundipharma International; Northside Hospital; PETHEMA Foundation; St. Jude Childrens Research Hospital; SymBio Pharmaceuticals; Teva Pharmaceutical Industries; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Benzimidazoles; Butyric acids; Nitrogen mustard compounds; Nitrosourea compounds; Small molecules
  • Mechanism of Action Alkylating agents; Antimetabolites; Apoptosis stimulants; DNA cross linking agents; DNA synthesis inhibitors; Mitosis modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mantle-cell lymphoma; Non-Hodgkin's lymphoma; Chronic lymphocytic leukaemia
  • New Molecular Entity No

Highest Development Phases

  • Marketed Breast cancer; Cancer; Chronic lymphocytic leukaemia; Hodgkin's disease; Mantle-cell lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma
  • Phase III Diffuse large B cell lymphoma
  • Phase II MALT lymphoma
  • Phase I Acute lymphoblastic leukaemia; Acute myeloid leukaemia
  • Discontinued Chronic myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 31 Aug 2017 Phase-III clinical trials in Diffuse large B cell lymphoma (Second-line therapy or greater) in Japan (IV)
  • 31 Aug 2017 SymBio plans to file an NDA application for Diffuse large B-cell lymphoma (Second line therapy or greater) in the second half of 2019
  • 10 Apr 2017 Genentech plans a phase II trial for Follicular lymphoma (First-line therapy, Combination therapy, Late-stage disease) (NCT03113422)
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