Apremilast

Drug Profile

Apremilast

Alternative Names: CC-10004; CC-1004; Otezla

Latest Information Update: 17 Jul 2017

Price : $50

At a glance

  • Originator Celgene Corporation
  • Developer Baylor Research Institute; Celgene Corporation
  • Class Anti-inflammatories; Antineoplastics; Antipsoriatics; Isoindoles; Phthalimides; Small molecules; Sulfones
  • Mechanism of Action Interleukin 23 inhibitors; Interleukin-10 expression stimulants; Tumour necrosis factor alpha inhibitors; Type 4 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Plaque psoriasis; Psoriatic arthritis
  • Preregistration Behcet's syndrome
  • Phase III Ankylosing spondylitis
  • Phase II Atopic dermatitis; Ulcerative colitis
  • Phase I Crohn's disease
  • No development reported Rheumatoid arthritis
  • Discontinued Asthma; Cancer

Most Recent Events

  • 24 Apr 2017 Celgene plans the STYLE phase III trial for Plaque psoriasis (NCT03123471)
  • 01 Mar 2017 Launched for Psoriatic arthritis and Plaque psoriasis in Japan (PO)
  • 09 Feb 2017 Celgene completes the phase III PALACE-3 trial in Psoriatic arthritis in USA, Canada, Australia, Switzerland, European Union, Russia and South Korea (PO) (NCT01212770)
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