Sapropterin

Drug Profile

Sapropterin

Alternative Names: 6R-BH4; BH4; Biopten; Kuvan; Phenoptin; Sapropterin dihydrochloride; SUN-0588; SUN0588r; Tetrahydrobiopterin

Latest Information Update: 04 Aug 2017

$50 / €47 *
* $ price applies to USA, Canada and Latin America. € price applies to the rest of the world. Final gross prices may vary according to local VAT.

At a glance

  • Originator Asubio Pharma; Daiichi Sankyo Company
  • Developer Asubio Pharma; BioMarin Pharmaceutical; Daiichi Sankyo Company
  • Class Anxiolytics; Nootropics; Pterins; Small molecules
  • Mechanism of Action Nitric oxide synthase stimulants; Phenylalanine hydroxylase stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Phenylketonuria
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Phenylketonuria
  • Discontinued Coronary disorders; Hypertension; Kidney disorders; Peripheral arterial disorders; Pulmonary hypertension; Sickle cell anaemia; Vascular disorders

Most Recent Events

  • 13 Apr 2017 BioMarin Pharmaceutical has patent protection for Sapropterin in Europe
  • 13 Apr 2017 BioMarin Pharmaceutical enters into a patent challenge settlement agreement with Par Pharmaceutical for a generic version of sapropterin in USA
  • 01 Oct 2015 Sapropterin licensed to BioMarin worldwide (except Japan)
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