Drug Profile


Alternative Names: ACZ-885; Anti-IL-1 beta monoclonal antibody; Anti-interleukin-1 beta monoclonal antibody; Antibody A; Ilaris

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Novartis
  • Developer Novartis; Triemli hospital; University Hospital Tubingen; University Hospital Zurich
  • Class Anti-inflammatories; Antihyperglycaemics; Antirheumatics; Cardiovascular therapies; Eye disorder therapies; Monoclonal antibodies
  • Mechanism of Action Interleukin 1 beta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Juvenile rheumatoid arthritis; Inflammation; Familial Mediterranean fever; Familial autosomal dominant periodic fever
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Adult-onset Still's disease; Cryopyrin-associated periodic syndromes; Familial autosomal dominant periodic fever; Familial Mediterranean fever; Gouty arthritis; Juvenile rheumatoid arthritis; Peroxisomal disorders
  • Phase III Behcet's syndrome; Cardiovascular disorders
  • Phase II Abdominal aortic aneurysm; Atherosclerosis; Osteoarthritis; Peripheral arterial occlusive disorders; Pulmonary sarcoidosis
  • Phase I Diabetic retinopathy
  • No development reported Chronic obstructive pulmonary disease
  • Discontinued Asthma; Polymyalgia rheumatica; Rheumatoid arthritis; Type 1 diabetes mellitus; Type 2 diabetes mellitus

Most Recent Events

  • 28 Aug 2017 Novartis plans phase III trials for Lung cancer
  • 27 Aug 2017 Efficacy and safety data from the phase III CANTOS trial in Cardiovascular disorders released by Novartis
  • 21 Jul 2017 Novartis terminates a phase II trial for Peripheral arterial occlusive disorders in USA, Germany and Jordan based on result from primary endpoint analysis (SC)(NCT01731990)
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