Drug Profile


Alternative Names: BMS-354825; Sprycel

Latest Information Update: 16 Jan 2017

Price : $50

At a glance

  • Originator Bristol-Myers Squibb
  • Developer Bristol-Myers Squibb; Dana-Farber Cancer Institute; Duke University Medical Center; Massachusetts General Hospital; Otsuka Pharmaceutical; Sarcoma Alliance for Research through Collaboration; University of Texas M. D. Anderson Cancer Center
  • Class Amides; Antineoplastics; Chlorobenzenes; Piperazines; Pyrimidines; Small molecules; Thiazoles
  • Mechanism of Action Bcr-abl tyrosine kinase inhibitors; EphA2 receptor antagonists; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein c-kit inhibitors; Src-Family kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic myeloid leukaemia; Acute lymphoblastic leukaemia
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute lymphoblastic leukaemia; Chronic myeloid leukaemia
  • Phase III Prostate cancer
  • Phase II Breast cancer; Cholangiocarcinoma; Chronic lymphocytic leukaemia; Sarcoma
  • Phase I/II Glioblastoma; Non-Hodgkin's lymphoma
  • Phase I Colorectal cancer; Leukaemia; Mesothelioma; Multiple myeloma; Non-small cell lung cancer
  • No development reported Malignant melanoma
  • Discontinued Pancreatic cancer; Scleroderma

Most Recent Events

  • 15 Mar 2016 Biomarkers information updated
  • 01 Jan 2016 Bristol-Myers Squibb completes a phase II trial in Chronic myeloid leukaemia (Newly diagnosed, First-line therapy, Combination therapy) in USA, Argentina, Belgium, Canada, Finland, France, Germany, Poland and Spain (NCT01357655)
  • 13 Aug 2015 The US FDA approves the product labeling update for dasatinib
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