Dasatinib

Drug Profile

Dasatinib

Alternative Names: BMS-354825; Sprycel

Latest Information Update: 16 Jun 2017

Price : $50

At a glance

  • Originator Bristol-Myers Squibb
  • Developer Bristol-Myers Squibb; Dana-Farber Cancer Institute; Massachusetts General Hospital; Otsuka Pharmaceutical; Sarcoma Alliance for Research through Collaboration; University of Texas M. D. Anderson Cancer Center; Weill Cornell Medical College
  • Class Amides; Antineoplastics; Chlorobenzenes; Piperazines; Pyrimidines; Small molecules; Thiazoles
  • Mechanism of Action Bcr-abl tyrosine kinase inhibitors; EphA2 receptor antagonists; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein c-kit inhibitors; Src-Family kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic myeloid leukaemia; Acute lymphoblastic leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute lymphoblastic leukaemia; Chronic myeloid leukaemia
  • Phase III Prostate cancer
  • Phase II Breast cancer; Cholangiocarcinoma; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Myeloproliferative disorders; Sarcoma
  • Phase I/II Glioblastoma; Non-Hodgkin's lymphoma
  • Phase I Colorectal cancer; Leukaemia; Mesothelioma; Multiple myeloma; Non-small cell lung cancer
  • No development reported Malignant melanoma
  • Discontinued Pancreatic cancer; Scleroderma

Most Recent Events

  • 05 Jun 2017 Efficacy and adverse events data from a phase II trial in Chronic myeloid leukaemia released by Bristol-Meyers Squibb
  • 19 May 2017 Preregistration for Chronic myeloid leukaemia (In adolescents, In children, Newly diagnosed) in European Union (PO) before May 2017
  • 03 Mar 2017 Bristol-Myers Squibb and M.D. Anderson Cancer Center completes a phase II trial in Myeloproliferative disorders (Second-line therapy or greater, Newly diagnosed) in USA (PO) (NCT00255346)
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