Drug Profile


Alternative Names: Anti CTLA 4 monoclonal antibody-Pfizer; CP-675; CP-675206; Ticilimumab

Latest Information Update: 12 Oct 2017

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At a glance

  • Originator Pfizer
  • Developer Amgen; AstraZeneca; Azienda Ospedaliera Universitaria Senese; Canadian Cancer Trials Group; Fondazione IRCCS Istituto Nazionale dei Tumori; Grupo Espanol de Tumores Neuroendocrinos; Immunocore; Institute Gustave-Roussy; Kyoto Breast Cancer Research Network; M. D. Anderson Cancer Center; MedImmune; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); National Health and Medical Research Council; Northwestern University; Pfizer; Seoul National University Hospital; University of Maryland Greenbaum Cancer Center
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; Interleukin 2 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Head and neck cancer; Mesothelioma; Non-small cell lung cancer; Small cell lung cancer; Solid tumours
  • Phase II Breast cancer; Endometrial cancer; Fallopian tube cancer; Gastric cancer; Germ cell and embryonal neoplasms; Glioblastoma; Hepatocellular carcinoma; Lung cancer; Neuroendocrine tumours; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Prostate cancer; Sarcoma
  • Phase I/II Colorectal cancer; Malignant melanoma; Oesophageal cancer
  • Phase I Diffuse large B cell lymphoma; Oropharyngeal cancer; Renal cell carcinoma; Thyroid cancer; Urogenital cancer
  • No development reported Gastrointestinal cancer

Most Recent Events

  • 09 Oct 2017 AstraZeneca plans the HIMALAYA phase III trial for Hepatocellular carcinoma (First-line treatment, Unresectable/Inoperable) in Brazil, Canada, France, Germany, Hong Kong, India, Italy, Japan, Russia, South Korea, Thailand, Ukraine, USA and Vietnam(NCT03298451)
  • 03 Oct 2017 MedImmune and Northwestern University suspends patient enrolment in a phase II trial for Breast cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT02536794)
  • 25 Sep 2017 University College and AstraZeneca plan the RAMPART phase III trial for Renal cell carcinoma (Combination therapy) (NCT03288532)
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