Drug Profile


Alternative Names: Anti CTLA 4 monoclonal antibody Pfizer; CP-675; CP-675206; Ticilimumab

Latest Information Update: 01 Jun 2017

Price : $50

At a glance

  • Originator Pfizer
  • Developer Amgen; AstraZeneca; Azienda Ospedaliera Universitaria Senese; Canadian Cancer Trials Group; Fondazione IRCCS Istituto Nazionale dei Tumori; Grupo Espanol de Tumores Neuroendocrinos; Immunocore; Kyoto Breast Cancer Research Network; M. D. Anderson Cancer Center; MedImmune; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); National Health and Medical Research Council; Northwestern University; Pfizer; Seoul National University Hospital
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; Interleukin 2 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Head and neck cancer; Mesothelioma; Non-small cell lung cancer; Small cell lung cancer; Solid tumours
  • Phase II Breast cancer; Endometrial cancer; Fallopian tube cancer; Gastric cancer; Germ cell and embryonal neoplasms; Glioblastoma; Hepatocellular carcinoma; Lung cancer; Neuroendocrine tumours; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Prostate cancer; Sarcoma
  • Phase I/II Malignant melanoma
  • Phase I Colorectal cancer; Diffuse large B cell lymphoma; Renal cell carcinoma; Thyroid cancer; Urogenital cancer
  • No development reported Gastrointestinal cancer

Most Recent Events

  • 02 Jun 2017 AstraZeneca plans the phase III POSEIDON trial in Non-small cell lung cancer (Combination therapy, First-line therapy, Metastatic disease) in USA, Hong Kong, South Korea, Peru, Russia, Taiwan, Ukraine and the United Kingdom (NCT03164616)
  • 02 Jun 2017 Ludwig Institute for Cancer Research, Cancer Research Institute, Boehringer Ingelheim, MedImmune, CureVac and PharmaJet plan a phase I/II trial for Non-small cell lung cancer (Metastatic disease, Combination therapy, Second-line therapy or greater) in USA (NCT03164772)
  • 18 May 2017 Phase-II clinical trials in Fallopian tube cancer (Combination therapy, Recurrent, Second-line therapy or greater) in USA (IV) (NCT03026062)
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