Palbociclib

Drug Profile

Palbociclib

Alternative Names: Ibrance; PD-0332991; PD-332991; PD-991; PF-332991

Latest Information Update: 23 Mar 2017

Price : $50

At a glance

  • Originator Onyx Pharmaceuticals; Pfizer
  • Developer Assistance Publique Hopitaux de Paris; Dana-Farber Cancer Institute; Georgetown University; German Breast Group; GlaxoSmithKline; iOMEDICO AG; Karolinska Institute; Merck & Co; National Cancer Institute (USA); Netherlands Cancer Institute; Northwestern University; Pfizer; UNC Lineberger Comprehensive Cancer Center; University of California at San Francisco
  • Class 2 ring heterocyclic compounds; Antineoplastics; Cyclopentanes; Ketones; Piperazines; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer
  • Phase II/III Non-small cell lung cancer
  • Phase II Brain metastases; Colorectal cancer; Head and neck cancer; Urogenital cancer
  • Phase I/II Cancer; Malignant melanoma
  • Phase I Mantle-cell lymphoma; Pancreatic cancer; Solid tumours
  • No development reported Glioblastoma; Multiple myeloma

Most Recent Events

  • 28 Feb 2017 Phase-I clinical trials in Solid tumours (Combination therapy, Late-stage disease, Metastatic disease) in USA (PO) (NCT03065062)
  • 28 Feb 2017 Pfizer plans a phase I trial for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease) in USA (NCT03065062)
  • 21 Feb 2017 University of Colorado plans a phase I/II trial for Breast cancer (Combination therapy, Metastatic disease, Inoperable/Unresectable) in USA (NCT03054363)
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