Drug Profile


Alternative Names: E-10030; E01AJ; Fovista; OAP-030; Pegpleranib sodium; X01E

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Archemix Corporation
  • Developer National Eye Institute; OphthoTech Corporation
  • Class Eye disorder therapies; Oligonucleotides; Peptide aptamers
  • Mechanism of Action Angiogenesis inhibitors; Platelet-derived growth factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Wet age-related macular degeneration
  • Phase I/II Von Hippel-Lindau disease

Most Recent Events

  • 28 Feb 2017 Ophthotech has patent protection for pegpleranib in USA, European union, Japan and other jurisdictions (Ophthotech form, 10-k, February 2017)
  • 28 Feb 2017 Ophthotech has patents pending for pegpleranib in USA, European union, Japan and other jurisdictions (Ophthotech form 10-k, February 2017)
  • 25 Jan 2017 OpthoTech terminates a phase II trial for Wet age-related macular degeneration (Combination therapy, In the elderly, Treatment-naive, In adults) in Netherlands, Estonia, Croatia and Czech Republic (Intravitreous) (EudraCT2015-000518-23)
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