Drug Profile


Alternative Names: KD-019; KD-020; Tesevatinib tosylate; XL-647

Latest Information Update: 12 Sep 2017

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At a glance

  • Originator Exelixis
  • Developer Exelixis; Kadmon Pharmaceuticals
  • Class Amines; Antineoplastics; Cyclopentanes; Pyrroles; Quinazolines; Small molecules
  • Mechanism of Action Protein tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Autosomal recessive polycystic kidney disease; Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase II Autosomal dominant polycystic kidney disease; Glioblastoma
  • Phase I Autosomal recessive polycystic kidney disease
  • No development reported Breast cancer; Hepatocellular carcinoma; Prostate cancer

Most Recent Events

  • 12 Sep 2017 No development reported - Phase-I/II for Breast cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in USA (PO) (Kadmon pipeline September 2017)
  • 09 Aug 2017 Kadmon Corporation initiates enrolment in a phase II trial for Autosomal-dominant polycystic kidney disease in USA (PO) (NCT03203642)
  • 08 Aug 2017 Tesevatinib receives Orphan Drug status for Non-small cell lung cancer in USA
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