Research programme: AMPK activators - Ligand Pharmaceuticals/Merck

Drug Profile

Research programme: AMPK activators - Ligand Pharmaceuticals/Merck

Alternative Names: MB 07562

Latest Information Update: 29 Mar 2010

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At a glance

  • Originator Metabasis Therapeutics
  • Developer Ligand Pharmaceuticals
  • Class Small molecules
  • Mechanism of Action AMP activated protein kinase stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Diabetes mellitus; Hyperlipidaemia

Most Recent Events

  • 29 Jan 2010 Metabasis Therapeutics has been acquired by Ligand Pharmaceuticals
  • 11 Jun 2009 Merck selects a lead candidate for late preclinical development under its 4-year research collaboration agreement with Metabasis
  • 24 Apr 2008 Metabasis and Merck extend their collaboration for AMPK aktivators for diabetes and other metabolic diseases
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