Drug Profile


Alternative Names: PF-04494700; PF-4494700; TTP-488

Latest Information Update: 05 Jun 2017

Price : $50

At a glance

  • Originator TransTech Pharma
  • Developer Pfizer; TransTech Pharma; vTv Therapeutics LLC
  • Class Antidementias; Diethylamines; Imidazoles; Small molecules
  • Mechanism of Action Advanced glycosylation end-product receptor antagonists; Amyloid inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Alzheimer's disease
  • Discontinued Diabetic nephropathies

Most Recent Events

  • 01 Jun 2017 vTv Therapeutics completes enrolment in the phase III STEADFAST trial in Alzheimer's disease in USA, Canada, Australia, Ireland, New Zealand, South Africa and United Kingdom
  • 01 Dec 2016 vTv Therapeutics initiates enrolment in the phase III STEADFAST trial for Alzheimer's disease in USA and Canada (NCT02916056)
  • 22 Sep 2016 vTv Therapeutics plans the phase III STEADFAST Extension trial for Alzheimer's disease (Treatment-experienced) in USA and Canada (PO) (NCT02916056)
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