Rigosertib

Drug Profile

Rigosertib

Alternative Names: Estybon; Novonex; ON-01910; ON-01910-sodium; ON-01910.Na; Rigosertib sodium; SyB 1101; SyB C-1101; SyB L-1101

Latest Information Update: 06 Oct 2017

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At a glance

  • Originator Onconova Therapeutics
  • Developer M. D. Anderson Cancer Center; Onconova Therapeutics; SymBio Pharmaceuticals
  • Class Amino acids; Antineoplastics; Small molecules; Sulfones
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; Polo-like kinase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer; Myelodysplastic syndromes
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Phase II Acute myeloid leukaemia; Myelofibrosis; Solid tumours
  • Phase I Head and neck cancer
  • No development reported Acute lymphoblastic leukaemia; Chronic lymphocytic leukaemia; Ovarian cancer; Pancreatic cancer
  • Discontinued Squamous cell cancer

Most Recent Events

  • 04 Oct 2017 Phase-II clinical trials in Acute myeloid leukaemia, Chronic myelomonocytic leukaemia and Myelodysplastic syndromes (Combination therapy) in Australia (PO) before October 2017
  • 16 Aug 2017 Phase-II clinical trials in Myelofibrosis in USA (PO) (NCT02730884)
  • 15 Aug 2017 Onconova Therapeutics in collaboration with the National Cancer Institute plans to initiate a clinical trial in Myelodysplastic syndromes (In children) in USA
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