Drug Profile


Alternative Names: ACT-293987; MRE-269; NS-304; Uptravi

Latest Information Update: 19 Sep 2017

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At a glance

  • Originator Nippon Shinyaku
  • Developer Actelion Pharmaceuticals; Nippon Shinyaku
  • Class Acetamides; Antihypertensives; Pyrazines; Small molecules; Sulfonamides; Vasodilators
  • Mechanism of Action Epoprostenol receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary arterial hypertension
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Pulmonary arterial hypertension
  • Phase III Arteriosclerosis obliterans; Pulmonary hypertension
  • Phase II Raynaud's disease

Most Recent Events

  • 21 Jun 2017 Actelion plans a phase III trial for Pulmonary arterial hypertension in Germany (NCT03187678) in October 2017
  • 16 Jun 2017 Actelion Pharmaceuticals has been acquired by Janssen Pharmaceuticals
  • 14 Feb 2017 Launched for Pulmonary arterial hypertension in Switzerland (PO), before February 2017
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