Ramucirumab

Drug Profile

Ramucirumab

Alternative Names: Anti-flk-1 monoclonal antibody - ImClone; Anti-KDR monoclonal antibody - ImClone; Anti-VEGFR 2 monoclonal antibody - ImClone; Cyramza; IMC-1121; IMC-1121-B; IMC-1C11 - ImClone; LY-3009806

Latest Information Update: 22 Dec 2016

Price : $50

At a glance

  • Originator Dyax
  • Developer AstraZeneca; Eli Lilly; Merck Sharp & Dohme; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatocellular carcinoma; Gastric cancer
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    Gastric cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Gastric cancer; Non-small cell lung cancer
  • Phase III Hepatocellular carcinoma; Urogenital cancer
  • Phase II Biliary cancer
  • Phase I Solid tumours
  • No development reported Breast cancer; Malignant melanoma; Ovarian cancer; Prostate cancer; Renal cell carcinoma

Most Recent Events

  • 02 Nov 2016 Eli Lilly and Company completes the phase III RAISE trial in Colorectal cancer (Second-line therapy or greater; Metastatic disease; Combination therapy) in USA, Argentina, Australia, Austria, Belgium, Brazil, Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, India, Israel, Italy, Japan, South Korea, Netherlands, Portugal, Puerto Rico, Romania, Slovenia, Spain, Sweden and Taiwan (NCT01183780)
  • 01 Nov 2016 Eli Lilly completes a phase Ib trial in Gastric cancer in Japan (NCT02359058)
  • 07 Oct 2016 Safety and efficacy results from phase Ia/b trial presented at the 41st European Society for Medical Oncology Congress
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