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Ramucirumab - Eli Lilly and Company

Drug Profile

Ramucirumab - Eli Lilly and Company

Alternative Names: Anti-flk-1 monoclonal antibody - ImClone; Anti-KDR monoclonal antibody - ImClone; Anti-VEGFR 2 monoclonal antibody - ImClone; Cyramza; IMC-1121; IMC-1121-B; IMC-1C11 - ImClone; LY-3009806; Ramcilumab; ramsilmab; Ramsilomab; Ramsylmab; Ramsylumab; Sairamza; Silamza

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Dyax
  • Developer AstraZeneca; Basilea Pharmaceutica; Dana-Farber Cancer Institute; Eli Lilly; Eli Lilly and Company; Merck Sharp & Dohme; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer; Gastric cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Gastric cancer; Liver cancer; Non-small cell lung cancer
  • Phase III Oesophageal cancer; Urogenital cancer
  • Phase II Biliary cancer; Carcinoid tumour; Solid tumours; Synovial sarcoma
  • Phase I/II Head and neck cancer; Pancreatic cancer; Soft tissue sarcoma
  • No development reported Adenocarcinoma; Breast cancer; Malignant melanoma; Ovarian cancer; Prostate cancer; Renal cell carcinoma

Most Recent Events

  • 02 Jun 2023 Efficacy and adverse events data from a phase II trial in non-small cell lung cancer presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
  • 23 Apr 2023 Eli Lilly and Company completes the phase Ib/II RACING study in Pancreatic cancer (First-line therapy, Late-stage disease, Second-line therapy or greater, Inoperable/Unresectable) in Greece (IV) (NCT03745430)
  • 19 Apr 2023 Eli Lilly and Company terminates a phase I/II trial in Synovial Sarcoma in US, Australia, Belgium, France, Germany, Japan, Italy, the Netherlands, Spain and the UK due to meeting protocol specified futility criteria (NCT04145700)
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