Drug Profile


Alternative Names: Anti-IFNaR MAb - Bristol-Myers Squibb/MedImmune; MDX-1333; MEDI-546

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Medarex
  • Developer Medarex; MedImmune
  • Class Monoclonal antibodies
  • Mechanism of Action Interferon alpha beta receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Systemic lupus erythematosus
  • No development reported Scleroderma

Most Recent Events

  • 14 Jun 2017 Adverse events, efficacy, immunogenicity data from a phase I trial in Healthy volunteers presented at the 18th Annual Congress of the European League Against Rheumatism (EULAR-2017)
  • 21 Feb 2017 Medimmune and Astrazenca completes a phase II trial in Systemic lupus erythematosus in Japan (IV) (NCT01559090)
  • 14 Feb 2017 Phase-II clinical trials in Systemic lupus erythematosus in USA, Hungary, South Korea (SC) (NCT02962960)
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