Nintedanib - Boehringer Ingelheim

Drug Profile

Nintedanib - Boehringer Ingelheim

Alternative Names: BIBF-1120; Intedanib; Ofev; Vargatef

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Boehringer Ingelheim
  • Developer Boehringer Ingelheim; European Organisation for Research and Treatment of Cancer; Roswell Park Cancer Institute
  • Class Acetamides; Antifibrotics; Antineoplastics; Esters; Indoles; Piperazines; Small molecules
  • Mechanism of Action Fibroblast growth factor receptor antagonists; Platelet derived growth factor alpha receptor antagonists; Platelet-derived growth factor beta receptor antagonists; Protein tyrosine kinase inhibitors; Type 1 fibroblast growth factor receptor antagonists; Type 3 fibroblast growth factor receptor antagonists; Type-2 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Interstitial lung diseases; Idiopathic pulmonary fibrosis; Systemic scleroderma; Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Idiopathic pulmonary fibrosis; Non-small cell lung cancer
  • Phase III Colorectal cancer; Interstitial lung diseases; Mesothelioma; Ovarian cancer; Systemic scleroderma
  • Phase II Bladder cancer; Endometrial cancer; Hepatocellular carcinoma; Renal cell carcinoma; Soft tissue sarcoma
  • No development reported Fallopian tube cancer; Multiple myeloma; Peritoneal cancer; Solid tumours
  • Discontinued Prostate cancer

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Fallopian-tube-cancer(Combination therapy) in Japan (PO, Capsule)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Fallopian-tube-cancer(Combination therapy, Late-stage disease, Second-line therapy or greater) in Spain (PO, Capsule)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Hepatocellular carcinoma in Japan (PO, Capsule)
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