Drug Profile


Alternative Names: Clearazide™; Ledaga; Mechlorethamine gel; Nitrogen mustard topical gel; Topical nitrogen mustard; Valchlor

Latest Information Update: 21 Dec 2016

Price : $50

At a glance

  • Originator Yaupon Therapeutics
  • Developer Actelion Pharmaceuticals
  • Class Antineoplastics; Nitrogen mustard compounds; Small molecules
  • Mechanism of Action Alkylating agents; T-cell receptor gene inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cutaneous T cell lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Marketed Mycosis fungoides

Most Recent Events

  • 16 Dec 2016 CHMP recommends approval of chlormethine for Mycosis fungoides in European Union (Topical)
  • 01 Jul 2015 Preregistration for Mycosis fungoides in Iceland, Liechtenstein, Norway and European Union (Topical) before July 2015
  • 01 Jul 2014 Actelion receives temporary authorisation for use ("ATU") for chlormethine in Mycosis fungoides in France after July 2014
Restricted Access

Oops, it looks like you don’t have a valid subscription to this content. To gain full access to the content and functionality of the AdisInsight database try one of the following.

  • with a username/password associated to an account with a valid subscription
  • Contact your organization’s admin about adding this content to your AdisInsight subscription
  • Request a trial

If you are a subscriber to this content then contact us at so we can help.

Back to top