Research programme: sirtuin activators - Sirtris

Drug Profile

Research programme: sirtuin activators - Sirtris

Alternative Names: SRT 1720; SRT 2172; SRT2183

Latest Information Update: 22 Dec 2009

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At a glance

  • Originator Sirtris Pharmaceuticals
  • Developer Sirtris
  • Class Small molecules
  • Mechanism of Action SIRT1 protein stimulants; Sirtuin stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Preclinical Amyotrophic lateral sclerosis; Cancer; Chronic obstructive pulmonary disease; Huntington's disease; Inflammation; Neurological disorders; Type 2 diabetes mellitus

Most Recent Events

  • 22 Dec 2009 Study information from a preclinical trial of some SIRT1 activators presented at the 51st Annual Meeting and Exposition of the American Society of Hematology, New Orleans (ASH-2009)
  • 17 Sep 2008 Sirtris exclusively licenses SIRT3-based intellectual property from Harvard University
  • 06 Jun 2008 Sirtris Pharmaceuticals has been acquired by GlaxoSmithKline
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