Trebananib

Drug Profile

Trebananib

Alternative Names: 20060439; AMG-386

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Amgen
  • Developer Amgen; Gynecologic Oncology Group; National Cancer Institute (USA); Roswell Park Cancer Institute; Takeda
  • Class Antibodies; Antineoplastics; Peptides; Recombinant fusion proteins
  • Mechanism of Action Angiogenesis inhibitors; Angiopoietin-1 inhibitors; Angiopoietin-2 inhibitors; TIE 2 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase II Breast cancer; Hepatocellular carcinoma; Renal cell carcinoma
  • Phase I/II Non-small cell lung cancer
  • Phase I Acute myeloid leukaemia; Solid tumours
  • No development reported Colorectal cancer; Endometrial cancer; Gastric cancer; Oesophageal cancer

Most Recent Events

  • 01 Dec 2016 Amgen terminates the phase III TRINOVA-3 trial in Ovarian, Fallopian tube & Peritoneal cancers (Combination therapy, First-line therapy) in USA, Canada, Austria, Belgium, Denmark, Germany, Greece, Italy, Netherlands, Russia, Spain, Hong Kong, Japan and South Korea (NCT01493505)
  • 01 Dec 2016 Amgen completes the global phase III TRINOVA-1 trial for Ovarian, Fallopian tube and Peritoneal cancers (Combination therapy, Second-line therapy or greater) (NCT01204749)
  • 03 Aug 2016 Roswell Park Cancer Institute in collaboration with Amgen completes a phase I trial in Acute myeloid leukaemia (Combination therapy) in USA (NCT01555268)
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