Trofinetide

Drug Profile

Trofinetide

Alternative Names: G-2Me-PE; Glycyl-2-methyl-L-prolyl-L-glutamic acid; Glycyl-L-2-methylprolyl-L-glutamic acid; NNZ-2566

Latest Information Update: 10 Jun 2017

Price : $50

At a glance

  • Originator Neuren Pharmaceuticals
  • Developer Neuren Pharmaceuticals; Rettsyndrome.org; Walter Reed Army Institute of Research
  • Class Glutamates; Neuropeptides; Neuroprotectants; Oligopeptides; Pyrrolidines; Small molecules
  • Mechanism of Action Cytokine inhibitors; Glial cell modulators; Neuropeptide receptor modulators; Synaptic transmission modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fragile X syndrome; Rett syndrome
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Brain injuries; Fragile X syndrome; Rett syndrome
  • Preclinical Autistic disorder; Multiple sclerosis

Most Recent Events

  • 31 May 2017 Neuren has composition of matter patent protection for trofinetide in Europe
  • 31 May 2017 Neuren receives patent allowance for trofinetide in the US for Fragile X syndrome and in Europe for Autistic disorders including Rett syndrome and Fragile X syndrome
  • 22 Mar 2017 Adverse event data from a phase II trial in Rett syndrome released by Neuren Pharmaceuticals
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