Drug Profile


Alternative Names: IPI-504; MEDI-561; Retaspimycin hydrochloride

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Infinity Pharmaceuticals
  • Developer Dana-Farber Cancer Institute; Infinity Pharmaceuticals; Massachusetts General Hospital
  • Class Antineoplastics; Benzoquinones; Macrocyclic lactams; Small molecules
  • Mechanism of Action HSP90 heat-shock protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastrointestinal stromal tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Gastrointestinal stromal tumours; Multiple myeloma; Non-small cell lung cancer; Prostate cancer

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 01 Oct 2014 Infinity Pharmaceuticals completes a phase I/II trial in Non-small cell lung cancer with KRAS mutation (combination therapy, second-line therapy) in USA (NCT01427946)
  • 01 Apr 2014 Infinity Pharmaceuticals completes a phase II trial in Non-small cell lung cancer in Taiwan, Russia, Romania, South Korea, Hungary and USA (NCT01362400)
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