Drug Profile


Alternative Names: FosD; Fostamatinib disodium; Fostamatinib sodium; R 985788; R-406/788; R-788; R-935/788; R788 sodium; R935788 sodium; Tamatinib fosdium; Tavalisse

Latest Information Update: 14 Nov 2017

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At a glance

  • Originator Rigel Pharmaceuticals
  • Developer AstraZeneca; Duke University Medical Center; Rigel Pharmaceuticals
  • Class Anti-inflammatories; Antianaemics; Antirheumatics; Oxazines; Phosphoric acid esters; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action B cell inhibitors; Syk kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Immune thrombocytopenic purpura
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preregistration Immune thrombocytopenic purpura
  • Phase II Autoimmune haemolytic anaemia; IgA nephropathy
  • Phase I Graft-versus-host disease
  • Discontinued Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Rheumatoid arthritis; Solid tumours; Systemic lupus erythematosus; T cell lymphoma; Type 1 diabetes mellitus

Most Recent Events

  • 07 Nov 2017 Updated adverse events data from a phase II trial in Autoimmune haemolytic anaemia released by Rigel Pharmaceuticals
  • 03 Oct 2017 Efficacy and adverse events data from a phase II trial in Autoimmune haemolytic anaemia released by Rigel Pharmaceuticals
  • 09 Aug 2017 Rigel Pharmaceuticals, in collaboration with Sidney Kimmel Comprehensive Cancer Center plans a phase I trial for Ovarian cancer (Combination therapy, In adults, In the elderly, Late-stage disease, Recurrent) in USA (NCT03246074)
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