Drug Profile


Alternative Names: BIW-8405; BIW-8405-IL-5R; KHK 4563; MEDI-563

Latest Information Update: 13 Sep 2017

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At a glance

  • Originator Kyowa Hakko
  • Developer AstraZeneca; Kyowa Hakko; Kyowa Hakko Kirin; MedImmune; National Jewish Medical and Research Center
  • Class Antiasthmatics; Monoclonal antibodies
  • Mechanism of Action Immunomodulators; Interleukin 5 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Asthma
  • Phase III Chronic obstructive pulmonary disease
  • Phase II Churg-Strauss syndrome; Hypereosinophilic syndrome; Rhinosinusitis

Most Recent Events

  • 11 Sep 2017 Pooled efficacy and adverse events data from the phase III SIROCCO and CALIMA trials in Asthma released by AstraZeneca
  • 13 Jul 2017 AstraZeneca completes a phase I pharmacokinetics trial in Healthy volunteers in Germany (SC) (NCT02968914)
  • 10 Jul 2017 AstraZeneca announces intention to submit regulatory application for Chronic obstructive pulmonary disease in Japan in 2019 (AstraZeneca pipeline, July 2017)
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