Drug Profile


Alternative Names: Anti-IL-5Rα Mab; Anti-IL5Ra monoclonal antibody - MediImmune; Anti-interleukin-5 receptor alpha monoclonal antibody - MedImmune; BIW-8405; BIW-8405-IL-5R; KHK 4563; MEDI-563

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Kyowa Hakko
  • Developer AstraZeneca; Kyowa Hakko; Kyowa Hakko Kirin; MedImmune; National Jewish Medical and Research Center
  • Class Antiasthmatics; Monoclonal antibodies
  • Mechanism of Action Immunomodulators; Interleukin 5 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Asthma; Chronic obstructive pulmonary disease
  • Phase II Churg-Strauss syndrome; Hypereosinophilic syndrome; Rhinosinusitis

Most Recent Events

  • 15 Apr 2017 Phase-II clinical trials in Churg-Strauss syndrome (Adjunctive treatment) in USA (SC) (NCT03010436)
  • 24 Mar 2017 Kyowa Hakko Kirin and AstraZeneca enter into agreement to develop and commercialise benralizumab in Asia for Asthma and Chronic obstructive pulmonary disease
  • 01 Jan 2017 AstraZeneca completes a phase III trial in Asthma (Adjunctive treatment, In adolescents) in USA (SC) (NCT02814643)
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