Cenicriviroc

Drug Profile

Cenicriviroc

Alternative Names: CCR5/CCR2 antagonist; Cenicriviroc mesylate; CVC; TAK-652; TBR-652

Latest Information Update: 05 May 2017

Price : $50

At a glance

  • Originator National Institute for Health Research; Takeda
  • Developer Dong-A ST; Imperial College of Science, Technology and Medicine; National Institute for Health Research; Tobira Therapeutics
  • Class Amides; Antifibrotics; Antineoplastics; Antiretrovirals; Imidazoles; Small molecules
  • Mechanism of Action CCR2 receptor antagonists; CCR5 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-alcoholic steatohepatitis
  • Phase II HIV-1 infections; Non-alcoholic fatty liver disease; Primary sclerosing cholangitis
  • Preclinical Cancer; Cholestasis; Diabetic nephropathies; Graft-versus-host disease; Liver disorders

Most Recent Events

  • 18 Apr 2017 Allergan in collaboration with Novartis plans a phase IIb trial for Non-alcoholic steatohepatitis (Combination therapy)
  • 04 Apr 2017 Phase-III clinical trials in Non-alcoholic steatohepatitis in USA and Puerto Rico (PO) (NCT03028740)
  • 01 Mar 2017 Tobira Therapeutics plans a phase II trial for Non-alcoholic steatohepatitis in USA, Australia, Belgium, France, Germany, Hong Kong, Italy, Poland, Spain and United Kingdom (NCT03059446)
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