Drug Profile


Alternative Names: Cenicriviroc mesylate; CVC; TAK-652; TBR-652

Latest Information Update: 03 Oct 2017

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At a glance

  • Originator National Institute for Health Research; Takeda
  • Developer Dong-A ST; Imperial College of Science, Technology and Medicine; National Institute for Health Research; Tobira Therapeutics
  • Class Amides; Antifibrotics; Antineoplastics; Antiretrovirals; Imidazoles; Small molecules
  • Mechanism of Action CCR2 receptor antagonists; CCR5 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-alcoholic steatohepatitis
  • Phase II HIV-1 infections; Non-alcoholic fatty liver disease; Primary sclerosing cholangitis
  • Preclinical Cancer; Cholestasis; Diabetic nephropathies; Graft-versus-host disease; Liver disorders

Most Recent Events

  • 22 Sep 2017 Adverse events and efficacy data from the phase IIb CENTAUR trial in Non-alcoholic steatohepatitis released by Allergan
  • 19 Apr 2017 Pharmakinetic and adverse events data from a phase I trial in healthy volunteers presented at the International Liver Congress 2017 (ILC-2017)
  • 18 Apr 2017 Allergan in collaboration with Novartis plans a phase IIb trial for Non-alcoholic steatohepatitis (Combination therapy)
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