Complement C1 inhibitor protein - Shire plc

Drug Profile

Complement C1 inhibitor protein - Shire plc

Alternative Names: C1 Esterase Inhibitor (human); C1 INH-nf; C1-INH; Cetor; Cinryze; SHP-616

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Sanquin Blood Supply Foundation
  • Developer Sanquin Blood Supply Foundation; Shire; Shire ViroPharma; ViroPharma
  • Class Complement C1 inactivator proteins; Vascular disorder therapies
  • Mechanism of Action Complement C1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Angioedema
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hereditary angioedema
  • Phase III Transplant rejection
  • Phase I Neuromyelitis optica
  • Clinical Phase Unknown Autoimmune haemolytic anaemia
  • Preclinical Delayed graft function
  • No development reported Myocardial infarction
  • Discontinued Paroxysmal nocturnal haemoglobinuria

Most Recent Events

  • 23 Jun 2017 Shire completes a phase III trial in Hereditary angioedema (In children, In adolescents, In adults, In the elderly) in Japan (NCT02865720)
  • 05 May 2017 Shire completes a phase III trial in Hereditary angioedema (In children, Prevention) in USA, Germany, Israel, Mexico, Romania and United Kingdom (NCT02052141)
  • 16 Mar 2017 Registered for Hereditary angioedema (In children) in European Union (IV)
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