Drug Profile


Alternative Names: M-402; M-ONC 402; M402 heparan sulfate

Latest Information Update: 05 Aug 2016

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At a glance

  • Originator Momenta Pharmaceuticals
  • Class Antineoplastics; Glycosaminoglycans; Sugar alcohols; Uronic acids
  • Mechanism of Action
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Pancreatic cancer

Most Recent Events

  • 04 Aug 2016 Momenta discontinues patient enrolment in a phase II trial in Pancreatic cancer (Combination therapy, Late-stage) due to lack of efficacy data
  • 04 Jun 2016 Efficacy, adverse events and pharmacokinetics data from a phase I/II trial in pancreatic cancer (First line therapy, Combination therapy, Metastatic disease) presented at the American Society of Clinical Oncology Annual meeting (ASCO-2016)
  • 21 Dec 2015 Momenta Pharmaceuticals re-initiates enrolment in the phase II MOM-M402-103 trial for Pancreatic cancer (First line therapy, Combination therapy, Metastatic disease) in USA and Canada
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