Drug Profile


Alternative Names: Anti-human Aβ28-40 IgG1; Antibody 2286; PF-04360365; PF-4,360,365; RN 1219

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Rinat Neuroscience
  • Developer Pfizer
  • Class Antidementias; Monoclonal antibodies
  • Mechanism of Action Amyloid beta-protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Alzheimer's disease; Cerebral amyloid angiopathy

Most Recent Events

  • 04 May 2016 Discontinued - Phase-II for Cerebral amyloid angiopathy in USA, United Kingdom, Canada, France, Netherlands (IV) (Pfizer pipeline, May 2016)
  • 01 Sep 2015 Pfizer completes a phase II trial in Cerebral amyloid angiopathy in USA, Canada, France, Netherlands and United Kingdom (IV) (NCT01821118)
  • 07 Nov 2014 Phase-II clinical trials in Cerebral amyloid angiopathy in France (IV)
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