Drug Profile


Alternative Names: AFQ-056

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Novartis
  • Class Alkynes; Antiparkinsonians; Anxiolytics; Esters; Indoles; Nitriles; Small molecules
  • Mechanism of Action Metabotropic glutamate receptor 5 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Obsessive-compulsive disorders
  • No development reported Chorea; Gastro-oesophageal reflux; Smoking withdrawal
  • Discontinued Anxiety disorders; Drug-induced dyskinesia; Fragile X syndrome

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 03 Oct 2016 Novartis plans a phase II trial for Fragile X Syndrome (Children) in USA (NCT02920892)
  • 09 Jun 2016 Novartis terminates a phase-II clinical trials in Obsessive-compulsive disorders in USA, Bulgaria, Czech Republic, Poland, Switzerland, United Kingdom and Germany as the study did not meet its primary efficacy objective(NCT01813019)
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