Bemcentinib - BerGenBio

Drug Profile

Bemcentinib - BerGenBio

Alternative Names: BGB 324; R-428

Latest Information Update: 22 Dec 2017

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At a glance

  • Originator Rigel Pharmaceuticals
  • Developer BerGenBio; Haukeland University Hospital; Merck Sharp & Dohme; University of Texas Southwestern Medical Center
  • Class Antineoplastics; Benzocycloheptenes; Cycloheptanes; Pyridazines; Pyrrolidines; Small molecules; Triazoles
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Malignant melanoma; Non-small cell lung cancer
  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes
  • No development reported Chronic myeloid leukaemia; Pancreatic cancer; Solid tumours

Most Recent Events

  • 14 Dec 2017 Efficacy data from phase I and phase I/II trials in Acute myeloid leukaemia and Non-small cell lung cancer released by BerGenBio
  • 11 Dec 2017 Interim efficacy and pharmacodynamics data from a phase Ib/II trial in acute myeloid leukaemia and myelodysplastic syndrome released by BerGenBio
  • 23 Nov 2017 Phase I development in Acute myeloid leukaemia (Combination therapy, Monotherapy, Second line therapy or greater) is still ongoing in Germany and USA
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