AT 9283

Drug Profile

AT 9283

Alternative Names: AT-9283

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Astex Therapeutics
  • Developer Astex Pharmaceuticals; Astex Therapeutics; Cancer Research UK; National Cancer Institute (Canada)
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Aurora kinase A inhibitors; Aurora kinase B inhibitors; Bcr-abl tyrosine kinase inhibitors; Janus kinase-2 inhibitors; STAT3 transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Medulloblastoma; Multiple myeloma; Myelofibrosis; Non-Hodgkin's lymphoma; Solid tumours

Most Recent Events

  • 11 Oct 2013 Astex Pharmaceuticals has been acquired by Otsuka Pharmaceutical
  • 09 Jan 2013 NCIC Clinical Trials Group completes a phase I trial in solid tumours and non-Hodgkin's lymphoma (second-line therapy or greater, monotherapy) in United Kingdom (NCT00443976)
  • 01 Dec 2012 Cancer Research UK completes a phase I trial in solid tumours (second-line therapy or greater, monotherapy, in children and adolescents) in United Kingdom (NCT00985868)
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