Daratumumab - Janssen Biotech

Drug Profile

Daratumumab - Janssen Biotech

Alternative Names: DARZALEX; Humanised anti-CD38 monoclonal antibody; HuMax-CD38; HuMax®-CD38 - Genmab; JNJ-54767414

Latest Information Update: 17 Nov 2017

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At a glance

  • Originator Genmab
  • Developer Boston Medical Center; Bristol-Myers Squibb; Genentech; Genmab; Janssen Biotech; Janssen Research & Development; M. D. Anderson Cancer Center
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma; Mantle-cell lymphoma; Follicular lymphoma; Diffuse large B cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Multiple myeloma
  • Phase III Amyloid light-chain amyloidosis
  • Phase II Acute myeloid leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Myelodysplastic syndromes; Prostate cancer; T cell lymphoma
  • Phase I/II Non-small cell lung cancer; Solid tumours
  • No development reported Chronic lymphocytic leukaemia

Most Recent Events

  • 14 Nov 2017 Launched for Multiple myeloma (Combination therapy, Second-line therapy or greater) in Japan (IV)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Multiple-myeloma(Combination therapy) in France (IV, Infusion)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Multiple-myeloma(Combination therapy) in Spain (IV, Infusion)
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