Drug Profile


Alternative Names: AST-726

Latest Information Update: 02 May 2014

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At a glance

  • Originator Ariston Pharmaceuticals
  • Developer TG Therapeutics Inc
  • Class Corrinoids; Vitamin B12 analogues; Vitamins
  • Mechanism of Action Vitamin B12 receptor protein agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Migraine; Vitamin deficiency

Most Recent Events

  • 07 Mar 2014 Discontinued - Phase-I for Vitamin deficiency in USA (Intranasal)
  • 07 Mar 2014 Discontinued - Phase-II for Migraine in European Union (Intranasal)
  • 08 Nov 2010 Manhattan Pharmaceuticals receives a Qualifying Therapeutic Discovery Project grant from the US Government for AST 726 development in Vitamin deficiency
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