Pexastimogene devacirepvec

Drug Profile

Pexastimogene devacirepvec

Alternative Names: JX-594; Pexa-Vec; TG-6006

Latest Information Update: 21 Apr 2017

Price : $50

At a glance

  • Originator Jennerex Biotherapeutics
  • Developer Green Cross; Jennerex; National Cancer Institute (France); SillaJen Biotherapeutics; Transgene
  • Class Antineoplastics; Oncolytic viruses
  • Mechanism of Action Apoptosis stimulants; Immunostimulants; Vascular disrupting agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatocellular carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hepatocellular carcinoma
  • Phase II Breast cancer; Renal cell carcinoma; Soft tissue sarcoma; Solid tumours
  • Phase I/II Malignant melanoma
  • Phase I Colorectal cancer
  • Preclinical Ovarian cancer; Pancreatic cancer

Most Recent Events

  • 21 Apr 2017 Transgene plans an exploratory phase II study in hepatocellular carcinoma (Late-stage disease; Combination therapy) in the US and Europe (NCT03071094)
  • 12 Apr 2017 Phase-II clinical trials in Breast cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in France (IV)
  • 12 Apr 2017 Phase-II clinical trials in Soft tissue sarcoma (Combination therapy, Late-stage disease, Second-line therapy or greater) in France (IV)
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