Research programme: RNAi therapeutics - Arbutus

Drug Profile

Research programme: RNAi therapeutics - Arbutus

Alternative Names: ARB-1740; LNP-siRNA therapeutics - Arbutus; TKM-ALDH; TKM-GSD; TKM-HTG; TKM-Marburg; WEE1/CSN5

Latest Information Update: 24 Feb 2017

Price : $50

At a glance

  • Originator Protiva Biotherapeutics
  • Developer Arbutus Biopharma
  • Class Gene therapies; Small interfering RNA
  • Mechanism of Action COPS5 protein inhibitors; RNA interference; WEE1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Marburg virus disease

Highest Development Phases

  • Preclinical Alcoholism; Hepatitis B; Hypertriglyceridaemia; Lysosomal storage diseases; Marburg virus disease; Non-alcoholic steatohepatitis; Solid tumours

Most Recent Events

  • 11 Nov 2016 Preclinical data in Hepatitis B infections presented at the 67th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD-2016)
  • 12 Oct 2016 Research programme: RNAi therapeutics - Arbutus is available for licensing as of 12 Oct 2016. http://arbutusbio.com/partners/partnering-licensing-opportunities.php
  • 08 Aug 2016 Arbutus receives patent issuance for Lipid nanoparticle (LNP) delivery technology in USA
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