Avibactam/ceftazidime

Drug Profile

Avibactam/ceftazidime

Alternative Names: AVE 1330/ceftazidime; AVE 1330A/ceftazidime; AVYCAZ; CAZ 104; CAZ-AVI; Ceftazidime/AVE 1330; Ceftazidime/AVE 1330A; Ceftazidime/NXL 104; NXL 104/ceftazidime; Zavicefta

Latest Information Update: 12 Nov 2016

Price : $50

At a glance

  • Originator Novexel
  • Developer Allergan; AstraZeneca; Cerexa; Novexel
  • Class Amides; Cephalosporins; Heterocyclic bicyclo compounds; Small molecules; Sulfates
  • Mechanism of Action Beta lactamase inhibitors; Cell wall inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity No

Highest Development Phases

  • Marketed Gram-negative infections; Intra-abdominal infections; Urinary tract infections
  • Registered Nosocomial pneumonia

Most Recent Events

  • 12 Oct 2016 US FDA accepts sNDA to review for avibactam/ceftazidime to update the label with new phase III trial results for Urinary tract infections
  • 11 Oct 2016 Allergan files sNDA for avibactam/ceftazidime to update the label with new phase III trial results for Urinary tract infections before October 2016
  • 09 Sep 2016 Forest Laboratories terminates a phase II trial for Febrile neutropenia (Combination therapy) prior to enrolment initiation in USA (IV, Infusion) (NCT02732327)
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