Demcizumab

Drug Profile

Demcizumab

Alternative Names: Anti-delta-like ligand 4 monoclonal antibody; Anti-DLL4 monoclonal antibody; OMP-18M21; OMP-21M18

Latest Information Update: 17 Apr 2017

Price : $50

At a glance

  • Originator OncoMed Pharmaceuticals
  • Developer Celgene Corporation; OncoMed Pharmaceuticals
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action DLL4 protein inhibitors; Stem cell inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-small cell lung cancer; Pancreatic cancer
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase I Solid tumours
  • No development reported Colorectal cancer

Most Recent Events

  • 10 Apr 2017 Efficacy and adverse events data from the phase II trial in Pancreatic cancer released by OncoMed
  • 10 Apr 2017 OncoMed terminates the phase II YOSEMITE trial in Pancreatic cancer in Australia, Belgium, Canada, Spain, USA and United Kingdom due to unfavourable results (NCT02289898)
  • 08 Mar 2017 OncoMed Pharmaceuticals intends to submit data from the phase II YOSEMITE and DENALI trials to Celgene for opt-in consideration in the first half of 2017
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