Isofagomine tartrate

Drug Profile

Isofagomine tartrate

Alternative Names: afegostat tartrate; AT 2101; HGT-3410; isofagomine-ERT combo therapy; Plicera; Plicera-ERT combo therapy

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Novo Nordisk; University of Maryland, Baltimore
  • Developer Amicus Therapeutics
  • Class Antihyperglycaemics; Imino pyranoses; Pharmacological chaperones; Piperidines; Small molecules
  • Mechanism of Action Glucosylceramidase stimulants; Protein folding stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gaucher's disease type I

Highest Development Phases

  • Preclinical Gaucher's disease type I
  • Discontinued Parkinson's disease

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 28 Feb 2012 Isofagomine tartrate is still in preclinical trials for Gaucher's disease (combination therapy) in US
  • 31 Jan 2012 Discontinued - Phase-II for Gaucher's disease type I in Germany (PO)
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