AT 7519

Drug Profile

AT 7519

Alternative Names: AT7519; AT7519M

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Astex Therapeutics
  • Developer Astex Pharmaceuticals; Astex Therapeutics; Multiple Myeloma Research Consortium; National Cancer Institute (Canada)
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Cyclin-dependent kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chronic lymphocytic leukaemia; Mantle-cell lymphoma; Multiple myeloma
  • Phase I Solid tumours

Most Recent Events

  • 01 Apr 2016 Phase-I clinical trials in Solid tumours (Combination therapy, Inoperable/Unresectable, Metastatic disease, Late-stage disease, Second-line therapy or greater) in USA (IV) (NCT02503709)
  • 11 Aug 2015 Phase-II development is ongoing for Multiple myeloma (Second-line therapy) in USA and Chronic lymphocytic leukaemia in Canada (Astex Pharmaceuticals pipeline, August 2015)
  • 24 Jul 2015 The National Cancer Institute plans a phase I trial (Combination therapy, Metastatic disease) for Solid tumours in USA (NCT02503709)
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