Drug Profile


Alternative Names: 856553; GS856553; GSK 856553; GW 856553; GW856553X

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator GlaxoSmithKline
  • Class Anti-inflammatories; Antiasthmatics; Antirheumatics; Cardiovascular therapies; Small molecules
  • Mechanism of Action P38 mitogen-activated protein kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute coronary syndromes
  • Phase II Chronic obstructive pulmonary disease; Focal segmental glomerulosclerosis
  • Phase I Inflammation
  • Discontinued Atherosclerosis; Dyslipidaemias; Major depressive disorder; Neuropathic pain; Rheumatoid arthritis

Most Recent Events

  • 13 May 2016 Efficacy data from the phase III EVOLUTION trial in Chronic obstructive pulmonary disease presented at the Conference of the American Thoracic Society (ATS-2016)
  • 01 May 2016 GlaxoSmithKline completes a phase II trial in Focal segmental glomerulosclerosis in USA and Canada (NCT02000440)
  • 07 Sep 2015 Phase-II development for Chronic obstructive pulmonary disease is ongoing in Argentina and South Korea
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