Drug Profile


Alternative Names: Histone deacetylase inhibitors - Italfarmaco; ITF-2357

Latest Information Update: 13 Feb 2017

Price : $50

At a glance

  • Originator Italfarmaco
  • Developer Italfarmaco; Radboud University
  • Class Amines; Antineoplastics; Carbamates; Hydroxamic acids; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors; Histone demethylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Polycythaemia vera; Juvenile rheumatoid arthritis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Myeloproliferative disorders
  • Phase I/II Duchenne muscular dystrophy; Polycythaemia vera
  • No development reported Hereditary autoinflammatory diseases; Juvenile rheumatoid arthritis
  • Discontinued Diffuse large B cell lymphoma; Hodgkin's disease; Multiple myeloma

Most Recent Events

  • 13 Feb 2017 No development reported - Phase-II for Hereditary autoinflammatory diseases in Netherlands (PO) (NCT00442182)
  • 15 Dec 2016 Biomarkers information updated
  • 28 Jul 2016 Italfarmaco plans a phase III trial in Duchenne muscular dystrophy (In children, In adolescents) in USA (NCT02851797)
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