Defibrotide

Drug Profile

Defibrotide

Alternative Names: Defibrotide sodium; Defitelio; Fraction P; JZP-381; Noravid; NS 73; Prociclide

Latest Information Update: 15 Jul 2017

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At a glance

  • Originator Gentium
  • Developer Fukushima Medical University; Gentium; Jazz Pharmaceuticals plc; Swedish Orphan Biovitrum
  • Class Antithrombotics; Nucleotide aptamers; Polydeoxyribonucleotides
  • Mechanism of Action Angiogenesis inhibitors; Heparanase inhibitors; Platelet aggregation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Graft-versus-host disease; Veno-occlusive disorders
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Marketed Veno-occlusive disorders
  • Preclinical Diabetic nephropathies; Graft-versus-host disease
  • Market Withdrawal Deep vein thrombosis; Thrombosis
  • No development reported Multiple myeloma

Most Recent Events

  • 02 Jun 2017 Efficacy and safety data from a phase III trial in Veno-occlusive disorders presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 30 Mar 2017 Jazz Pharmaceuticals and Nippon Shinyaku agree to co-promote and co-develop defibrotide in Japan for Veno-occlusive disorders
  • 06 Feb 2017 Fukushima Medical University Hospital completes a phase II trial in Veno-occlusive disorders in Japan (UMIN000013454)
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