GEN 1

Drug Profile

GEN 1

Alternative Names: EGEN-001; GEN-1 IL-12 DNA-based immunotherapy - Celsion; IL-12 gene therapy - Celsion Corporation; IL-12 gene therapy - EGEN; IL-12 gene therapy - Expression Genetics; Interleukin-12 gene therapy - Celsion Corporation; Interleukin-12 gene therapy - EGEN; Interleukin-12 gene therapy - Expression Genetics; phIL-12-005/PPC

Latest Information Update: 08 Jan 2018

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At a glance

  • Originator Expression Genetics
  • Developer Celsion Corporation; Gynecologic Oncology Group
  • Class Cytokine genes; Gene therapies; Immunotherapies; Interleukins
  • Mechanism of Action Gene transference; Immunomodulators; Interleukin 12 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • No development reported Colorectal cancer; Glioblastoma

Most Recent Events

  • 04 Jan 2018 US FDA approves protocol for the phase I/II OVATION II trial for Ovarian cancer (Late-stage disease, Newly-diagnosed, Adjuvant therapy)
  • 14 Nov 2017 Updated efficacy data from a phase Ib trial in Ovarian cancer released by Celsion
  • 13 Nov 2017 Celsion Corporation submits a phase I/II trial protocol to the US FDA for Ovarian cancer (Late-stage disease, Newly-diagnosed, Adjuvant therapy)
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