Roxadustat

Drug Profile

Roxadustat

Alternative Names: ASP 1517; FG-4592

Latest Information Update: 16 Jun 2017

Price : $50

At a glance

  • Originator FibroGen
  • Developer Astellas Pharma; AstraZeneca; FibroGen
  • Class Amides; Antianaemics; Carboxylic acids; Isoquinolines; Small molecules
  • Mechanism of Action Basic helix loop helix transcription factor modulators; Hypoxia-inducible factor-proline dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Anaemia
  • Discontinued Sickle cell anaemia

Most Recent Events

  • 05 Jun 2017 European Patent Office gave a decision against FibroGen for an opposition filed by Akebia Therapeutics, Bayer Group, and Glaxo Group for the European patent number 2 322 155, related to the therapeutic use of certain small molecule inhibitors of hypoxia-inducible factor (HIF) prolyl hydroxylase, in Europe
  • 31 Mar 2017 China Food and Drug Administration (CFDA) approves Clinical Trial Application for roxadustat in Anaemia (associated with myelodysplastic syndrome)
  • 31 Mar 2017 FibroGen plans a phae II/III trial for Anaemia (associated with Myelodysplastic syndrome) in China
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