Drug Profile


Alternative Names: ASP 1517; AZD 9941; FG-4592

Latest Information Update: 04 Oct 2017

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At a glance

  • Originator FibroGen
  • Developer Astellas Pharma; AstraZeneca; FibroGen
  • Class Amides; Antianaemics; Carboxylic acids; Isoquinolines; Small molecules
  • Mechanism of Action Basic helix loop helix transcription factor modulators; Hypoxia-inducible factor-proline dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Anaemia
  • Discontinued Sickle cell anaemia

Most Recent Events

  • 07 Sep 2017 FibroGen initiates enrolment in a phase III trial for Anaemia (associated with Myelodysplastic syndrome) in Spain and USA (PO) (NCT03263091) (EudraCT2017-001773-17)
  • 07 Aug 2017 FibroGen announces intention to submit NDA to US FDA for Anaemia in 2018
  • 02 Aug 2017 Astellas Pharma completes a phase III trial for Anaemia (In chronic kidney disease patients undergoing peritoneal dialysis) in Japan (PO) (NCT02780726)
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