Raltegravir

Drug Profile

Raltegravir

Alternative Names: Isentress; L 900612; MK-0518

Latest Information Update: 25 May 2017

Price : $50

At a glance

  • Originator Merck & Co
  • Developer Merck & Co; The French National Agency for Research on AIDS and Viral Hepatitis
  • Class Antiretrovirals; Naphthyridines; Organic chemicals; Small molecules
  • Mechanism of Action HIV integrase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - HIV-1 infections
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed HIV-1 infections

Most Recent Events

  • 19 May 2017 Committee for Medicinal Products for Human Use (CHMP) recommends approval of raltegravir for HIV-1 infections (Combination therapy, Treatment naive) in European Union
  • 28 Feb 2017 Merck has patent protection for raltegravir in Europe and Japan (Merck 10-K, filed in Feb 2017)
  • 01 Dec 2016 Merck completes the phase-III ONCEMRK trial in HIV-1 infections (Combination therapy, Treatment-naive patients) in Italy, Spain, Portugal, Belgium, United Kingdom, Germany, France, Australia, Canada, Chile, USA (PO, 1200mg once daily) (EudraCT2013-001939-47) (NCT02131233)
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