Apatinib

Drug Profile

Apatinib

Alternative Names: Apatinib mesylate; YN-968-D1

Latest Information Update: 10 Jul 2017

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At a glance

  • Originator Advenchen Laboratories LLC
  • Developer Bukwang Pharmaceutical; Fudan University Shanghai Cancer Center; Jiangsu Hengrui Medicine Co.; LSK Biopharma
  • Class Amides; Antineoplastics; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Proto oncogene protein c ret inhibitors; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gastric cancer
  • Phase III Hepatocellular carcinoma; Non-small cell lung cancer
  • Phase II Breast cancer; Colorectal cancer; Solid tumours
  • Phase I Fallopian tube cancer; Ovarian cancer; Peritoneal cancer

Most Recent Events

  • 14 Aug 2017 Jiangsu HengRui Medicine plans a phase I trial for Solid tumours (Late-stage disease) in China (NCT03245307)
  • 02 Jun 2017 Phase-I clinical trials in Gastric cancer (In volunteers) in USA (PO) before June 2017
  • 02 Jun 2017 Pharmacokinetics data from a phase I trial in Gastric cancer presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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