Afatinib

Drug Profile

Afatinib

Alternative Names: BIBW 2992 MA2; BIBW-2992; Gilotrif; Giotrif; Tomtovok; Tovok

Latest Information Update: 29 Dec 2016

Price : $50

At a glance

  • Originator Boehringer Ingelheim
  • Developer AIO Studien gGmbH; Boehringer Ingelheim; European Organisation for Research and Treatment of Cancer
  • Class Antineoplastics; Quinazolines; Radiation-sensitising agents; Small molecules
  • Mechanism of Action Epidermal growth factor receptor antagonists; ERBB 2 receptor antagonists; ERBB 4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase III Breast cancer; Head and neck cancer
  • Phase II Glioma; Urogenital cancer
  • Phase I Glioblastoma; Rhabdomyosarcoma; Solid tumours
  • No development reported Colorectal cancer; Prostate cancer

Most Recent Events

  • 01 Dec 2016 Boehringer Ingelheim initiates enrolment in the phase II DARWIN1 trial for Non-small cell lung cancer in United Kingdom (NCT02183883)
  • 29 Nov 2016 Adverse events and efficacy data from a phase Ib trial in Solid tumours (including head and neck cancer, and non-small cell lung cancer) presented at the 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
  • 09 Oct 2016 Efficacy data from the LUX-Lung 7 phase II trial in Non-small lung cancer released by Boehringer Ingelheim
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