Afatinib

Drug Profile

Afatinib

Alternative Names: BIBW 2992 MA2; BIBW-2992; Gilotrif; Giotrif; Tomtovok; Tovok; Xovoltib

Latest Information Update: 14 Jul 2017

Price : $50

At a glance

  • Originator Boehringer Ingelheim
  • Developer Boehringer Ingelheim; European Organisation for Research and Treatment of Cancer; European Thoracic Oncology Platform; H. Lee Moffitt Cancer Center and Research Institute
  • Class Antineoplastics; Quinazolines; Radiation-sensitising agents; Small molecules
  • Mechanism of Action Epidermal growth factor receptor antagonists; ERBB 2 receptor antagonists; ERBB 4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer; CNS cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase III Breast cancer; Head and neck cancer
  • Phase II Glioma; Urogenital cancer
  • Phase I Glioblastoma; Rhabdomyosarcoma; Solid tumours
  • No development reported Colorectal cancer; Prostate cancer

Most Recent Events

  • 02 Jun 2017 Adverse events and efficacy data from a subgroup analysis of phase III LUX-head and neck 2 trial in Head and neck cancer presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 30 May 2017 Boehringer Ingelheim plans the phase II LUX-Lung IO trial for Non-small cell lung cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA, Spain and Turkey (NCT03157089)
  • 21 Mar 2017 Phase-II clinical trials in Head and neck cancer (Second-line therapy or greater, Combination therapy, Metastatic disease, Recurrent) in USA (PO) (NCT02979977)
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