Research programme: vitamin D analogues - Aphios

Drug Profile

Research programme: vitamin D analogues - Aphios

Alternative Names: 1,25(OH)2D3-3-BE; AMPI-109; APH-0701; APH-1201; APH-M109; MPI-105; MPI-106; MPI-107

Latest Information Update: 20 Oct 2014

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At a glance

  • Originator Boston University School of Medicine
  • Developer Aphios Corporation
  • Class Antineoplastics; Dihydroxycholecalciferols
  • Mechanism of Action Apoptosis stimulants; Calcitriol stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Prostate cancer

Most Recent Events

  • 20 Oct 2014 Active development in Prostate cancer (hormone refractory) (IV) is ongoing in the US
  • 22 Jun 2009 Preclinical development is ongoing
  • 20 Sep 2007 Aphios receives STTR grant from the National Cancer Institute for development of MPI 109 in hormone-refractory Prostate cancer
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