Drug Profile


Alternative Names: ARQ-197

Latest Information Update: 12 Nov 2016

Price : $50

At a glance

  • Originator ArQule
  • Developer ArQule; Daiichi Sankyo Company; Istituto Clinico Humanitas; Istituto Oncologico Veneto; Kyowa Hakko Kirin; National Cancer Institute (USA); National Institutes of Health (USA); SCRI Development Innovations
  • Class Antineoplastics; Pyrrolidinones; Quinolines; Small molecules
  • Mechanism of Action Proto oncogene protein c met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hepatocellular carcinoma
  • Phase II Colorectal cancer; Head and neck cancer; Mesothelioma; Multiple myeloma; Prostate cancer; Renal cell carcinoma; Small cell lung cancer
  • Phase I/II Solid tumours
  • Discontinued Gastric cancer; Germ cell and embryonal neoplasms; Non-small cell lung cancer; Pancreatic cancer; Soft tissue sarcoma

Most Recent Events

  • 13 Jul 2016 Daiichi Sankyo completes a phase I trial for Solid tumours (in patients with hepatic impairment) in USA (NCT02150733)
  • 15 Mar 2016 Biomarkers information updated
  • 29 Feb 2016 Pharmacodynamics data from the phase III METIV-HCC trial in Hepatocellular carcinoma released by ArQule
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