Drug Profile


Alternative Names: Efficib; Januet; Janumet; Metformin hydrochloride mixture with sitagliptin phosphate; MK-0431A; ONO 5434A; ONO-5435A; Ristfor; Sitagliptin/metformin; Velmetia

Latest Information Update: 22 Aug 2017

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At a glance

  • Originator Merck & Co
  • Class Antihyperglycaemics; Biguanides; Insulin sensitisers; Pyrazines; Small molecules; Triazoles
  • Mechanism of Action AMP activated protein kinase stimulants; CD26 antigen inhibitors; Gluconeogenesis inhibitors; Glucose modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Type 2 diabetes mellitus

Most Recent Events

  • 22 Aug 2017 Chemical structure information added
  • 14 Aug 2017 Sitagliptin/metformin is still in phase III trials for Type-2 diabetes mellitus (In adolescents, In children) in countries worldwide (NCT01472367) (EudraCT2011-002529-23)
  • 07 Apr 2017 Merck receives complete response letter from the FDA for sitagliptin/metformin treatment of patients with Type 2 diabetes mellitus
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